Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

doi:10.1101/gad.9.22.2736

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Article

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

Genes & development - 15 Nov 1995

Beg A A, Sha W C, Bronson R T, Baltimore D

Abstract excerpt

Transcription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins, mainly I kappa B alpha and I kappa B beta. Apparently normal at birth, I kappa B alpha-/- mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days. Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some,...

Topics

Animals
Animals, Newborn
Base Sequence
DNA Primers
DNA-Binding Proteins
Female
Fibroblasts
Gene Expression Regulation
Genes, Lethal
Granulocytes
Humans
I-kappa B Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Molecular Sequence Data

NF-KappaB Inhibitor alpha

NF-kappa B

NF-kappa B p50 Subunit

Source

Open in PubMed

Identifiers

PMID: 7590249
DOI: 10.1101/gad.9.22.2736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7590249-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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