Article
Lessons learned from molecular defects in nuclear factor kappaB dependent signaling.
Microbes and infection - 1 Apr 2006
McDonald Douglas R, Janssen Riny, Geha Raif
Abstract excerpt
Nuclear factor (NF) kappaB is a ubiquitously expressed transcription factor that plays critical roles in normal development and inflammation. Characterization of naturally occurring defects in signaling pathways leading to activation of NFkappaB, complemented by mouse knockout models, has demonstrated the vital role of NFkappaB in normal host defense.
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