Article
[Idiotypic T-lymphocyte receptor in animal and human autoimmune diseases].
Revue du rhumatisme (Ed. francaise : 1993) - 1 Jan 1994
Kay R A, Ollier W E
Abstract excerpt
Animal models have demonstrated that the T-cell repertoire is restricted when the response to defined autoantigens is studied. Anti-V beta specific monoclonal antibodies or specific V beta-derived peptides can be used to manipulate autoreactive T-cells to either prevent or treat established experimental disease in animals. In some animal models of arthritis, inherited differences in the TCR repertoire can protect...
Topics
- Animals
- Autoimmune Diseases
- Disease Susceptibility
- Gene Expression Regulation
- Genes
- Genetic Variation
- Humans
- Receptors, Antigen, T-Cell