Article
[Idiotypic T-lymphocyte receptor in animal and human autoimmune diseases].
Revue du rhumatisme (Ed. francaise : 1993) - 1 Jan 1994
Kay R A, Ollier W E
Abstract excerpt
Animal models have demonstrated that the T-cell repertoire is restricted when the response to defined autoantigens is studied. Anti-V beta specific monoclonal antibodies or specific V beta-derived peptides can be used to manipulate autoreactive T-cells to either prevent or treat established experimental disease in animals. In some animal models of arthritis, inherited differences in the TCR repertoire can protect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
