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Article

Characterization of an acid-resistant mutant of foot-and-mouth disease virus.

Virology - 10 Jan 1995

Twomey T, France L L, Hassard S, Burrage T G, Newman J F, Brown F

Abstract excerpt

A foot-and-mouth disease virus mutant which is stable at pH 6.4 has been isolated from a virus of serotype A. In contrast to the parent (P) virus, which gave a mixture of large and small plaques in BHK21 cells and in a bovine kidney cell line, the acid-resistant (AR) virus gave small plaques whic...

Topics

Animals
Animals, Suckling
Aphthovirus
Cell Line
Cricetinae
Electrophoresis, Polyacrylamide Gel
Hydrogen-Ion Concentration
Isoelectric Focusing
Mice
Microscopy, Electron
Mutation
Sequence Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Nonstructural Proteins

Virus Replication

Source

Identifiers

PMID: 7831827
DOI: 10.1016/s0042-6822(95)80020-4

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7831827-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Characterization of an acid-resistant mutant of foot-and-mouth disease virus.PMID 7831827Read ↗

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid lability and confer resistance to acid-dependent uncoating inhibition.Semantic proximity Read ↗

Targeted Modification of the Foot-And-Mouth Disease Virus Genome for Quick Cell Culture AdaptationSemantic proximity Read ↗

Role of a single amino acid substitution of VP3 H142D for increased acid resistance of foot-and-mouth disease virus serotype A.Semantic proximity Read ↗

Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus.Semantic proximity Read ↗

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Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability.Semantic proximity Read ↗

Establishment of persistent infection with foot-and-mouth disease virus in BHK-21 cellsSemantic proximity Read ↗

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Engineering viable foot-and-mouth disease viruses with increased thermostability as a step in the development of improved vaccines.Semantic proximity Read ↗

An increase in acid resistance of foot-and-mouth disease virus capsid is mediated by a tyrosine replacement of the VP2 histidine previously associated with VP0 cleavage.Semantic proximity Read ↗

Characterization of synthetic foot-and-mouth disease virus provirions separates acid-mediated disassembly from infectivitySemantic proximity Read ↗

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