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Characterization of synthetic foot-and-mouth disease virus provirions separates acid-mediated disassembly from infectivity

1 Apr 1997

Abstract excerpt

One of the final steps in the maturation of foot-and-mouth disease virus (FMDV) is cleavage of the VP0 protein to produce VP4 and VP2. The mechanism of this cleavage is unknown, but it is thought to function in stabilizing the virus particle and priming it for infecting cells. To investigate the cleavage process and to understand its role in virion maturation, we engineered synthetic FMDV RNAs with mutations at...

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PMID: 9060641
DOI: 10.1128/jvi.71.4.2851-2856.1997

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