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Article

Engineering viable foot-and-mouth disease viruses with increased thermostability as a step in the development of improved vaccines.

Journal of virology - 1 Dec 2008

Mateo Roberto, Luna Eva, Rincón Verónica, Mateu Mauricio G

Abstract excerpt

We have rationally engineered foot-and-mouth disease virus to increase its stability against thermal dissociation into subunits without disrupting the many biological functions needed for its infectivity. Amino acid side chains located near the capsid intersubunit interfaces and either predicted or found to be dispensable for infectivity were replaced by others that could establish new disulfide bonds or...

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Identifiers

PMID: 18829763
DOI: 10.1128/JVI.01553-08
PMCID: PMC2593342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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