Article
Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines.
Applied microbiology and biotechnology - 1 Feb 2020
Yuan Hong, Li Pinghua, Bao Huifang, Sun Pu, Bai Xingwen, Bai Qifeng, Li Na, Ma Xueqing, Cao Yimei, Fu Yuanfang, Li Kun, Zhang Jing, Li Dong, Chen Yingli, Zhang Jie, Lu Zengjun, Liu Zaixin
Abstract excerpt
Foot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses, tends to disassemble into pentamers at pH values slightly below neutrality. However, the structural integrity of intact virion is one of the most important factors that influence the induction of a protective antibody response. Thus, improving the acid stability of FMDV is required for the efficacy of vaccine preparations....
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