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Establishment of persistent infection with foot-and-mouth disease virus in BHK-21 cells

14 Apr 2011

Abstract excerpt

BACKGROUND: Foot-and-mouth disease virus (FMDV) is able to cause persistent infection in ruminants besides acute infection and disease. Since the mechanisms of viral persistence and the determining factors are still unknown, in vitro systems help explore and reveal mechanisms of persistence in vivo by providing useful models for the study of RNA genome mutations and evolution. Ammonium chloride, a lysosomotropic...

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PMID: 21492421
DOI: 10.1186/1743-422x-8-169

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