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Article

Rapid selection in modified BHK-21 cells of a foot-and-mouth disease virus variant showing alterations in cell tropism.

Journal of virology - 1 Dec 1998

Escarmís C, Carrillo E C, Ferrer M, Arriaza J F, Lopez N, Tami C, Verdaguer N, Domingo E, Franze-Fernández M T

Abstract excerpt

With persistent foot-and-mouth disease virus (FMDV) in BHK-21 cells, there is coevolution of the cells and the resident virus; the virulence of the virus for the parental BHK-21 cells is gradually increased, and the cells become partially resistant to FMDV. Here we report that variants of FMDV C3Arg/85 were selected in a single infection of partially resistant BHK-21 cells (termed BHK-Rb cells). Indirect...

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Identifiers

PMID: 9811758
DOI: 10.1128/JVI.72.12.10171-10179.1998
PMCID: PMC110560

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