Article
Rapid selection in modified BHK-21 cells of a foot-and-mouth disease virus variant showing alterations in cell tropism.
Journal of virology - 1 Dec 1998
Escarmís C, Carrillo E C, Ferrer M, Arriaza J F, Lopez N, Tami C, Verdaguer N, Domingo E, Franze-Fernández M T
Abstract excerpt
With persistent foot-and-mouth disease virus (FMDV) in BHK-21 cells, there is coevolution of the cells and the resident virus; the virulence of the virus for the parental BHK-21 cells is gradually increased, and the cells become partially resistant to FMDV. Here we report that variants of FMDV C3...
Topics
- Amino Acid Substitution
- Animals
- Aphthovirus
- CHO Cells
- Capsid
- Capsid Proteins
- Cell Line
- Cricetinae
- Cytopathogenic Effect, Viral
- Genetic Variation
- Genotype
- Models, Molecular
- Mutation
- Phenotype
- Protein Conformation