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Article

Relationship between the murine Ah phenotype and the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Shen E S, Olson J R

Abstract excerpt

The influence of the Ah locus on the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was studied using isolated hepatocytes from Ah responsive C57BL/6J (C57) and nonresponsive DBA/2J (DBA) mice. Hepatocytes from control and TCDD-pretreated C57 and DBA mice were incubated with purified [14C] TCDD (2.2 microM) for 8 hr in the metabolism studies or 2 hr in the uptake studies. Mice were...

Topics

Animals
Benzo(a)pyrene
Chromatography, High Pressure Liquid
Dioxins
Lethal Dose 50
Liver
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polychlorinated Dibenzodioxins

Receptors, Aryl Hydrocarbon

Receptors, Drug

Source

Identifiers

PMID: 2891482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2891482-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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