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Article

Molecular cloning of chicken aggrecan. Structural analyses.

The Biochemical journal - 15 Dec 1992

Chandrasekaran L, Tanzer M L

Abstract excerpt

The large, aggregating chondroitin sulphate proteoglycan of cartilage, aggrecan, has served as a generic model of proteoglycan structure. Molecular cloning of aggrecans has further defined their amino acid sequences and domain structures. In this study, we have obtained the complete coding sequence of chicken sternal cartilage aggrecan by a combination of cDNA and genomic DNA sequencing. The composite sequence is...

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Identifiers

PMID: 1339285
DOI: 10.1042/bj2880903
PMCID: PMC1131972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular cloning of chicken aggrecan. Structural analyses.PMID 1339285Read ↗

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A human-specific polymorphism in the coding region of the aggrecan gene. Variable number of tandem repeats produce a range of core protein sizes in the general population.Semantic proximity Read ↗

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan.Semantic proximity Read ↗

The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage.Semantic proximity Read ↗

Role of the C-terminal G3 domain in sorting and secretion of aggrecan core protein and ubiquitin-mediated degradation of accumulated mutant precursors.Semantic proximity Read ↗

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