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Article

Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.

Molecular and cellular biology - 1 Dec 1996

Zhao Q, Weiss A

Abstract excerpt

The protein tyrosine kinase ZAP-70 plays an essential role in T-cell activation and development. After T-cell receptor stimulation, ZAP-70 is associated with the receptor and is phosphorylated on many tyrosine residues, including tyrosine 292 (Y-292), in the region between the C-terminal SH2 domain and the kinase domain (interdomain B). Here we show that a mutation of Y-292 (292F) or deletion of interdomain B...

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Identifiers

PMID: 8943331
DOI: 10.1128/MCB.16.12.6765
PMCID: PMC231679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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