Article
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
Molecular and cellular biology - 1 Dec 1996
Zhao Q, Weiss A
Abstract excerpt
The protein tyrosine kinase ZAP-70 plays an essential role in T-cell activation and development. After T-cell receptor stimulation, ZAP-70 is associated with the receptor and is phosphorylated on many tyrosine residues, including tyrosine 292 (Y-292), in the region between the C-terminal SH2 doma...
Topics
- Gene Expression Regulation
- Humans
- Jurkat Cells
- Lymphocyte Activation
- Mutation
- Protein-Tyrosine Kinases
- Receptors, Antigen, T-Cell
- T-Lymphocytes
- ZAP-70 Protein-Tyrosine Kinase