Article
Multidrug resistance and the role of P-glycoprotein knockout mice.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2000
Schinkel A H, Mol C A, Wagenaar E, van Deemter L, Smit J J, Borst P
Abstract excerpt
Drug resistance, be it intrinsic or acquired, is a major problem in cancer chemotherapy. In vitro, one well characterised form of resistance against many different cytotoxic drugs is caused by the MDR1 P-glycoprotein, a large plasma membrane protein that protects the cell by actively pumping substrate drugs out. Available evidence suggests that this protein may cause drug resistance in at least some clinical...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Mice
- Mice, Knockout
- Phenotype