Article
Evaluating limited specificity of drug pumps reduced relative resistance in human MDR phenotypes.
European journal of biochemistry - 1 Sept 2000
Jongsma A P, Riethorst A, Lankelma J, Dekker H, Westerhoff H V
Abstract excerpt
In the parallel paper, we developed a property to characterize drug efflux pumps, i.e. the reduced relative resistance (RRR). Using this RRR, we here investigate whether the observed diversity in human multidrug resistance (MDR) phenotypes might be due to variable levels of P-glycoprotein encoded by MDR1. We analyzed resistance phenotypes of various human cell lines in which either one, or both, classical human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.