Article
Detection of UV-Induced Deletions in Mitochondrial DNA.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023
Fontana Gabriele A, Gahlon Hailey L
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are found in several human pathologies and are associated with aging. Deletion mutations in mtDNA result in the loss of essential genes for mitochondrial function. Over 250 deletion mutations have been reported and the common deletion is the most frequent mtDNA deletion linked to disease. This deletion removes 4977 base pairs of mtDNA. It has previously been shown that exposure...
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