Article
Photoageing-associated mitochondrial DNA length mutations in human skin.
Archives of dermatological research - 1 Jan 1995
Yang J H, Lee H C, Wei Y H
Abstract excerpt
It has recently been suggested that mitochondrial DNA (mtDNA) mutations are important contributors to human ageing and degenerative diseases. Using PCR techniques, we demonstrated three types of mtDNA length mutations, a 4977 bp deletion, a 7436 bp deletion and tandem duplications, in normal human skin tissues. We found that these mutations started to appear in the third decade of life, and the age at which the...
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