Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of an atrial natriuretic peptide variant that is specific for type A receptor.

The EMBO journal - 1 Jun 1994

Cunningham B C, Lowe D G, Li B, Bennett B D, Wells J A

Abstract excerpt

Receptor-specific variants of atrial natriuretic peptide (ANP) were selected from libraries of filamentous phage particles that displayed single copies of random ANP mutants fused to gene III protein. These ANP variants were differentially selected by binding to immobilized natriuretic peptide receptor A (NPR-A) over competing receptor C (NPR-C) in solution. This method also selected ANP variants with improved...

Topics

Amino Acid Sequence
Atrial Natriuretic Factor
Bacteriophages
Base Sequence
DNA Mutational Analysis
Gene Library
Genetic Techniques
Genetic Vectors
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Receptors, Atrial Natriuretic Factor

Recombinant Fusion Proteins

Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 8013451
DOI: 10.1002/j.1460-2075.1994.tb06540.x
PMCID: PMC395124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8013451-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production of an atrial natriuretic peptide variant that is specific for type A receptor.PMID 8013451Read ↗

Mutations in B-type natriuretic peptide mediating receptor-A selectivity.Semantic proximity Read ↗

Dominant negative mutations of the guanylyl cyclase-A receptor. Extracellular domain deletion and catalytic domain point mutations.Semantic proximity Read ↗

A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions.Semantic proximity Read ↗

Precision Aptamers Against a Native GPCR through Ligand-Guided SelectionSemantic proximity Read ↗

Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide.Semantic proximity Read ↗

Single mutations at Asn295 and Leu305 in the cytoplasmic half of transmembrane alpha-helix domain 7 of the AT1 receptor induce promiscuous agonist specificity for angiotensin II fragments: a pseudo-constitutive activity.Semantic proximity Read ↗

A constitutively "phosphorylated" guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitization.Semantic proximity Read ↗

Selection of novel ligands from a whole-molecule randomly mutated C5a library.Semantic proximity Read ↗

An in vitro-selected RNA receptor for the GAAC loop: modular receptor for non-GNRA-type tetraloop.Semantic proximity Read ↗

Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.Semantic proximity Read ↗

Ligand-independent oligomerization of natriuretic peptide receptors. Identification of heteromeric receptors and a dominant negative mutant.Semantic proximity Read ↗

Enhanced ouabain resistance gene as a eukaryotic selection marker.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.