Article
Mutational inactivation of the catalytic domain of guanylate cyclase-A receptor.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 1995
Miao Z H, Song D L, Douglas J G, Chang C H
Abstract excerpt
Guanylate cyclase-A, the receptor for atrial natriuretic factor, contains a protein kinase-like domain and a catalytic domain in the intracellular region. To investigate the active site (the catalytic cavity) of guanylate cyclase-A, we amplified the catalytic domain plus three amino acids from the kinase-like domain of guanylate cyclase-A (GC-c) with polymerase chain reaction (PCR) and expressed it in Escherichia...
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