Article
The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis.
The Journal of biological chemistry - 6 Jan 1995
Huang Z, Chen Y, Nissenson R A
Abstract excerpt
The present studies were done to evaluate the role of the cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein (PTHrP) in the endocytosis of agonist-occupied receptors. PTH/PTHrP receptor mutants progressively truncated from the C terminus were...
Topics
- Amino Acid Sequence
- Animals
- Cattle
- Cell Line
- Cytoplasm
- Endocytosis
- GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Protein Binding
- Receptor, Parathyroid Hormone, Type 1
- Receptors, Parathyroid Hormone
- Signal Transduction