Article
Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity.
The Journal of biological chemistry - 14 Mar 1997
Iida-Klein A, Guo J, Takemura M, Drake M T, Potts J T, Abou-Samra A, Bringhurst F R, Segre G V
Abstract excerpt
To define the structural requirements of the parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor necessary for activation of phospholipase C (PLC), receptors with random mutations in their second cytoplasmic loop were synthesized, and their properties were assessed. A mutant in which the wild type (WT) rat PTH/PTHrP receptor sequence EKKY (amino acids 317-320) was replaced with DSEL had little or no...
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