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Article

Functional analysis of a type 1 parathyroid hormone receptor intracellular tail mutant [KRK(484-6)AAA]: effects on second messenger generation and cellular targeting.

Bone - 1 Apr 2010

Patterson Eric K, Hodsman Anthony B, Hendy Geoffrey N, Canaff Lucie, Bringhurst F Richard, Fraher Laurence J

Abstract excerpt

The parathyroid hormone receptor type 1 (PTHR1) is activated by parathyroid hormone (PTH) and PTH-related protein (PTHrP) and primarily signals via intracellular pathways involving adenylyl cyclase and phospholipase C. The intracellular tail domain of the PTHR1 contributes to G protein subunit coupling that is important for second messenger signalling. In addition, the intracellular domain has a potential nuclear...

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Source

Identifiers

PMID: 20006743
DOI: 10.1016/j.bone.2009.12.005

Genes

PTH

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Functional analysis of a type 1 parathyroid hormone receptor intracellular tail mutant [KRK(484-6)AAA]: effects on second messenger generation and cellular targeting.PMID 20006743Read ↗

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