Article
Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.
Endocrinology - 1 Oct 1994
Lee C, Gardella T J, Abou-Samra A B, Nussbaum S R, Segre G V, Potts J T, Kronenberg H M, Jüppner H
Abstract excerpt
The PTH/PTH-related peptide receptor is a member of a newly discovered family of G-protein-coupled receptors. Strikingly conserved features among these receptors include the positioning of eight extracellular cysteines and several other residues that are located predominantly within the membrane-embedded region. Deletion mutants or receptors with point mutations of the highly conserved cysteine residues were...
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