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Article

Novel nucleolar and nuclear morphology in a vincristine-dependent human leukemia cell line (L100).

Experimental cell research - 1 Jan 1992

Slater L M, Sweet P, Hsu T C, Chan P K

Abstract excerpt

Acquired resistance to chemotherapeutic drugs by tumor cells is an important obstacle to effective therapy of human malignancy. We now describe a vincristine (VCR)-induced multidrug-resistant (MDR) human acute lymphatic leukemia cell line, the sustained in vitro growth of which is dependent on vincristine. The doubling time for parental drug-sensitive cells (L0) is 40.2 +/- 13.2 h and for the MDR subline (L100)...

Topics

Cell Cycle
Cell Nucleolus
Cell Nucleus
Colchicine
Cytoskeleton
Drug Resistance
Fluorescent Antibody Technique
Humans
Phenotype
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vincristine

Source

Identifiers

PMID: 1727053
DOI: 10.1016/0014-4827(92)90164-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1727053-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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