Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stable ornithine decarboxylase in a rat hepatoma cell line selected for resistance to alpha-difluoromethylornithine.

Archives of biochemistry and biophysics - 1 Oct 1991

Mitchell J L, Hoff J A, Bareyal-Leyser A

Abstract excerpt

Ornithine decarboxylase (ODC) is extremely unstable in mammalian cells. This unusual characteristic facilitates rapid fluctuations in the activity of this enzyme in response to variations in its biosynthesis. Unfortunately, very little is known about the mechanism or regulation of this ODC-specific proteolytic pathway. This study describes the production and characterization of a variant of the rat hepatoma HTC...

Topics

Animals
Cell Line
Drug Resistance
Eflornithine
Genetic Variation
Kinetics
Liver Neoplasms, Experimental
Ornithine Decarboxylase
Ornithine Decarboxylase Inhibitors
Rats
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1898085
DOI: 10.1016/0003-9861(91)90600-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1898085-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Stable ornithine decarboxylase in a rat hepatoma cell line selected for resistance to alpha-difluoromethylornithine.PMID 1898085Read ↗

Single amino-acid replacement is responsible for the stabilization of ornithine decarboxylase in HMOA cells.Semantic proximity Read ↗

PC12 variants with altered ornithine decarboxylase expression patterns exhibit altered signal transduction capabilities.Semantic proximity Read ↗

Multiple regulation of ornithine decarboxylase in enzyme-overproducing cells.Semantic proximity Read ↗

Molecular and genetic characterization of an ornithine decarboxylase-deficient Chinese hamster cell line.Semantic proximity Read ↗

Alpha-difluoromethylornithine resistance in Leishmania donovani is associated with increased ornithine decarboxylase activity.Semantic proximity Read ↗

Multiple active conformers of mouse ornithine decarboxylase.Semantic proximity Read ↗

A Trypanosoma brucei bloodstream form mutant deficient in ornithine decarboxylase can protect against wild-type infection in mice.Semantic proximity Read ↗

Effect of mutations at active site residues on the activity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors.Semantic proximity Read ↗

Asparagine markedly induces the expression of ornithine decarboxylase gene in transformed mammalian cells but not in their untransformed counterparts.Semantic proximity Read ↗

Alpha-difluoromethylornithine-resistant cell lines obtained after one-step selection of Leishmania mexicana promastigote cultures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.