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Article

Cell-cycle checkpoints. Keeping mitosis in check.

Current biology : CB - 1 Apr 1995

Humphrey T, Enoch T

Abstract excerpt

Mutations in an essential yeast gene, encoding DNA polymerase epsilon, abolish the dependence of mitosis on the completion of DNA replication, suggesting that the replication complex provides the checkpoint signal.

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Identifiers

PMID: 7627552
DOI: 10.1016/s0960-9822(95)00077-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Cell-cycle checkpoints. Keeping mitosis in check.PMID 7627552Read ↗

DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability.Semantic proximity Read ↗

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Analysis of the Functionality of the Mitotic Checkpoints.Semantic proximity Read ↗

DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.Semantic proximity Read ↗

Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.Semantic proximity Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiae.Semantic proximity Read ↗

S-phase checkpoint activity and function throughout the cell cycleSemantic proximity Read ↗

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.Semantic proximity Read ↗

Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint.Semantic proximity Read ↗

Safeguarding entry into mitosis: the antephase checkpoint.Semantic proximity Read ↗

Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth.Semantic proximity Read ↗

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