Glycoprotein gp50-negative pseudorabies virus: a novel approach toward a nonspreading live herpesvirus vaccine.

doi:10.1128/JVI.67.3.1529-1537.1993

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Article

Glycoprotein gp50-negative pseudorabies virus: a novel approach toward a nonspreading live herpesvirus vaccine.

Journal of virology - 1 Mar 1993

Heffner S, Kovács F, Klupp B G, Mettenleiter T C

Abstract excerpt

Essential herpesvirus glycoproteins are involved in membrane fusion processes during infection, e.g., viral penetration and direct cell-to-cell transmission. We previously showed that the gD-homologous glycoprotein gp50 of pseudorabies virus (PrV) is essential for virus entry into target cells bu...

Topics

Animals
Female
Gene Deletion
Genes, Viral
Genetic Complementation Test
Herpesviridae Infections
Herpesvirus 1, Suid
Immunotherapy, Active
Mice
Mice, Inbred BALB C
Mutation
Swine
Vaccines
Viral Envelope Proteins
Virulence

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