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Article

Control of B cells expressing naturally occurring autoantibodies.

Advances in experimental medicine and biology - 1 Jan 2012

Pasquali Jean Louis, Martin Thierry

Abstract excerpt

Naturally occurring autoantibodies (NAbs) are typically polyreactive, bind with low affinity to a discrete set of autoantigens and are encoded by variable region genes in germline configuration. They differ from disease-associated autoantibodies (autoAb), which are mostly monoreactive, somatically mutated and of high affinities. Structure-function studies have shown that polyreactivity of NAbs relies on the...

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Identifiers

PMID: 22903672
DOI: 10.1007/978-1-4614-3461-0_11

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