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Article

Autoreactivity of primary human immunoglobulins ancestral to hypermutated human antibodies that neutralize HCMV.

Molecular immunology - 1 May 2006

McLean Gary R, Cho Chin-wen, Schrader John W

Abstract excerpt

The human antibody response to the AD-2S1 epitope of glycoprotein B (gB) of human cytomegalovirus (HCMV) is dominated by a family of closely related somatically mutated antibodies. These antibodies neutralize viral infectivity and the genes encoding them are derived from two commonly used germ-line variable (V) region genes, IGHV3-30 and IGKV3-11. Recombination of these V genes with the appropriate junctional...

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Identifiers

PMID: 16423397
DOI: 10.1016/j.molimm.2005.11.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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