Article
A class I MHC-restricted recall response to a viral peptide is highly polyclonal despite stringent CDR3 selection: implications for establishing memory T cell repertoires in "real-world" conditions.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1998
Naumov Y N, Hogan K T, Naumova E N, Pagel J T, Gorski J
Abstract excerpt
In this study, we analyze the recall response to influenza A matrix peptide M1(58-66) restricted by HLA-A2 in one individual and find a strict CDR3 selection as well as a high degree of polyclonality. The TCR beta-chain repertoire of memory T cells specific for this Ag system has been shown previ...
Topics
- Hematopoietic Stem Cells
- Histocompatibility Antigens Class I
- Humans
- Immunologic Memory
- Influenza A virus
- Lymphocyte Activation
- Mutation
- Peptide Fragments
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes, Cytotoxic