Article
The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype.
Journal of virology - 1 Jan 2002
Boon A C M, de Mutsert G, Graus Y M F, Fouchier R A M, Sintnicolaas K, Osterhaus A D M E, Rimmelzwaan G F
Abstract excerpt
The repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses has been shown to be directed towards multiple epitopes, with a dominant response to the HLA-A2-restricted M1(58-66) epitope. These studies, however, were performed with peripheral blood mononuclear cells (PBMC) of individuals selected randomly with respect to HLA phenotype or selected for the expression of one HLA allele...
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