Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influenza A antigen exposure selects dominant Vβ17+ TCR in human CD8+ cytotoxic T cell responses

1 Nov 2001

Abstract excerpt

During acute human viral infections, such as influenza A, specific cytotoxic T lymphocytes (CTL) are generated which aid virus clearance. We have observed that in HLA-A*0201+ subjects, CTL expressing Vbeta17+ TCR and recognizing a peptide from the influenza A matrix protein (M1(58-66)) dominate this response. In experimental models of infection such dominance can be due to inheritance of a restricted T cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Influenza Virus Research Studies
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11675369
DOI: 10.1093/intimm/13.11.1373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influenza A antigen exposure selects dominant Vβ17+ TCR in human CD8+ cytotoxic T cell responsesPMID 11675369Read ↗

Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment.Semantic proximity Read ↗

Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus InfectionSemantic proximity Read ↗

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cellsSemantic proximity Read ↗

Molecular basis for universal HLA-A*0201–restricted CD8 <sup>+</sup> T-cell immunity against influenza virusesSemantic proximity Read ↗

A class I MHC-restricted recall response to a viral peptide is highly polyclonal despite stringent CDR3 selection: implications for establishing memory T cell repertoires in "real-world" conditions.Semantic proximity Read ↗

Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph.Semantic proximity Read ↗

The Immunodominant Influenza A Virus M158–66Cytotoxic T Lymphocyte Epitope Exhibits Degenerate Class I Major Histocompatibility Complex Restriction in HumansSemantic proximity Read ↗

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 diseaseSemantic proximity Read ↗

Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderlySemantic proximity Read ↗

Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.Semantic proximity Read ↗

Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adultsSemantic proximity Read ↗

Differential Recognition of Influenza A Viruses by M158–66Epitope-Specific CD8+T Cells Is Determined by Extraepitopic Amino Acid ResiduesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.