Flow cytometric analysis of lymphocyte subpopulations in the spleen and thymus of mice exposed to an acute immunosuppressive dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

doi:10.1016/s0013-9351(05)80249-x

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Article

Flow cytometric analysis of lymphocyte subpopulations in the spleen and thymus of mice exposed to an acute immunosuppressive dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Environmental research - 1 Aug 1990

Kerkvliet N I, Brauner J A

Abstract excerpt

The objective of the present studies was to determine if acute exposure to an immunotoxic dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces alterations in the expression of lymphocyte surface markers as measured by multiparameter flow cytometry. The immunotoxicity of a single oral dose...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface
CD4 Antigens
CD8 Antigens
Dioxins
Dose-Response Relationship, Drug
Female
Flow Cytometry
Immune Tolerance
Leukocyte Count
Lymphocytes
Mice
Mice, Inbred C57BL
Phenotype
Polychlorinated Dibenzodioxins
Spleen
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 2118453
DOI: 10.1016/s0013-9351(05)80249-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2118453-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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