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Article

K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2008

Etienne-Grimaldi Marie-Christine, Formento Jean-Louis, Francoual Mireille, François Eric, Formento Patricia, Renée Nicole, Laurent-Puig Pierre, Chazal Maurice, Benchimol Daniel, Delpero Jean-Robert, Letoublon Christian, Pezet Denis, Seitz Jean-François, Milano Gérard

Abstract excerpt

PURPOSE: K-Ras mutations predict resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies. Because combinations of anti-EGFR with 5-fluorouracil (5-FU)-based chemotherapy are promising treatments, we analyzed the effect of K-Ras mutations in patients having received exclusive 5-FU therapy. EXPERIMENTAL DESIGN: This study was conducted on 93 stage IV colorectal cancer patients with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18676755
DOI: 10.1158/1078-0432.CCR-07-4906

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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