Article
Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Jan 2001
Schiller J H, Adak S, Feins R H, Keller S M, Fry W A, Livingston R B, Hammond M E, Wolf B, Sabatini L, Jett J, Kohman L, Johnson D H
Abstract excerpt
PURPOSE: To determine the prognostic and predictive significance of p53 and K-ras mutations in patients with completely resected non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Patients were randomized preoperatively to receive adjuvant postoperative radiotherapy (Arm A) or radiotherapy plus concurrent chemotherapy (Arm B). p53 protein expression was studied by immunohistochemistry (IHC) and p53...
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