Article
Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival.
International journal of cancer - 20 May 2001
Rosty C, Chazal M, Etienne M C, Letoublon C, Bourgeon A, Delpero J R, Pezet D, Beaune P, Laurent-Puig P, Milano G
Abstract excerpt
In vitro and clinical studies have suggested that high-frequency microsatellite instability (MSI-H) phenotype, p53 and K-ras mutations might influence the response to chemotherapy in a variety of tumors, including primary colorectal cancers (CRC). Unresectable hepatic metastases from CRC are commonly treated with 5-fluorouracil (5FU) and folinic acid. Since several new active drugs are now used for treating CRC,...
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