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Article

Angiotensinogen in human essential hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 1996

Caulfield M, Lavender P, Newell-Price J, Kamdar S, Farrall M, Clark A J

Abstract excerpt

The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are...

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PMID: 8952609
DOI: 10.1161/01.hyp.28.6.1123

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