Article
Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2010
Grobe Justin L, Dickson Matthew E, Park Sungmi, Davis Deborah R, Born Ella J, Sigmund Curt D
Abstract excerpt
Genetic and functional data support a role for angiotensinogen in blood pressure control, and many population studies have suggested that polymorphisms in the angiotensinogen gene contribute to hypertension. Two common haplotypes of the human angiotensinogen gene are -6A/235T and -6G/235M. To study their contributions to blood pressure regulation in a controlled model system, we developed triple-transgenic mice...
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