Article
CAF-1 is required for efficient replication of euchromatic DNA in Drosophila larval endocycling cells.
Chromosoma - 1 Apr 2009
Klapholz Benjamin, Dietrich Bruce H, Schaffner Catherine, Hérédia Fabiana, Quivy Jean-Pierre, Almouzni Geneviève, Dostatni Nathalie
Abstract excerpt
The endocycle constitutes an effective strategy for cell growth during development. In contrast to the mitotic cycle, it consists of multiple S-phases with no intervening mitosis and lacks a checkpoint ensuring the replication of the entire genome. Here, we report an essential requirement of chromatin assembly factor-1 (CAF-1) for Drosophila larval endocycles. This complex promotes histone H3-H4 deposition onto...
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