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Article

A role for the unfolded protein response in optimizing antibody secretion.

Molecular immunology - 1 Jul 2004

Gunn Kathryn E, Gifford Nicole M, Mori Kazutoshi, Brewer Joseph W

Abstract excerpt

Terminal differentiation of B lymphocytes into antibody(Ab)-secreting plasma cells is marked by a sharp rise in immunoglobulin (Ig) biosynthesis that increases demand on the protein folding capacity of the endoplasmic reticulum (ER). The unfolded protein response pathway (UPR) allows cells to respond to challenging conditions within the ER, in part by the activities of the XBP1 and ATF6alpha/beta transcription...

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Source

Identifiers

PMID: 15261464
DOI: 10.1016/j.molimm.2004.04.023

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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