Article
Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum.
The Journal of cell biology - 1 Nov 1991
Valetti C, Grossi C E, Milstein C, Sitia R
Abstract excerpt
Dilated cisternae of the ER resembling Russell Bodies (RBs) are induced in light (L) chain producing myeloma cell lines by transfection of a mu heavy (H) chain gene lacking the first constant domain (mu delta CH1). RBs do not appear to be tissue specific, since they are also induced in a rat glio...
Topics
- Amino Acid Sequence
- Animals
- Cell Compartmentation
- Cysteine
- Endoplasmic Reticulum
- Glioma
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Kinetics
- Mice
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Plasmacytoma
- Rats
- SOS Response, Genetics
- Transfection
- Tumor Cells, Cultured