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Article

pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.

Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2009

Shimizu Yuichiro, Meunier Laurent, Hendershot Linda M

Abstract excerpt

Plasma cells can synthesize and secrete thousands of Ig molecules per second, which are folded and assembled in the endoplasmic reticulum (ER) and are likely to place unusually high demands on the resident chaperones and folding enzymes. We have discovered a new resident ER protein (pERp1) that is a component of the BiP chaperone complex. PERp1 is substantially up-regulated during B to plasma cell differentiation...

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Identifiers

PMID: 19805157
DOI: 10.1073/pnas.0811591106
PMCID: PMC2761359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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