Article
Recombination rate estimation in the presence of hotspots.
Genome research - 1 Aug 2007
Auton Adam, McVean Gil
Abstract excerpt
Fine-scale estimation of recombination rates remains a challenging problem. Experimental techniques can provide accurate estimates at fine scales but are technically challenging and cannot be applied on a genome-wide scale. An alternative source of information comes from patterns of genetic variation. Several statistical methods have been developed to estimate recombination rates from randomly sampled...
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