Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glnk Mediates Carbapenem Resistance Through the NtrB/NtrC-OprD Regulatory Pathway in Pseudomonas aeruginosa.

Pathogens (Basel, Switzerland) - 6 Mar 2026

Sun Xiaomeng, Li Yiming, Gong Xuetao, Du Qitong, Jin Yongxin, Cheng Zhihui, Jin Shouguang, Wu Weihui

Abstract excerpt

Pseudomonas aeruginosa is a major causative agent of nosocomial infections worldwide. Carbapenems are the first-line agents for combating severe P. aeruginosa infections. However, the increasing prevalence of carbapenem-resistant P. aeruginosa (CRPA) has developed as a critical threat to global healthcare systems. In this study, we demonstrated that a mutation in the core nitrogen metabolism regulatory gene glnK...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to beta-Lactam Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carbapenems

Share to Drug Resistance, Bacterial

Share to Gene Expression Regulation, Bacterial

Share to Microbial Sensitivity Tests

Share to Porins

Share to Pseudomonas aeruginosa

Source

Open in PubMed Open full text

Identifiers

PMID: 41901741
DOI: 10.3390/pathogens15030289
PMCID: PMC13029640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glnk Mediates Carbapenem Resistance Through the NtrB/NtrC-OprD Regulatory Pathway in Pseudomonas aeruginosa.PMID 41901741Read ↗

NtrBC Selectively Regulates Host-Pathogen Interactions, Virulence, and Ciprofloxacin Susceptibility of Pseudomonas aeruginosaSemantic proximity Read ↗

Transcriptional regulator NtrC modulates nitrogen assimilation, virulence, and the extracellular glutamine synthetase activity in Acinetobacter baumannii.Semantic proximity Read ↗

Role of the Outer Membrane Protein OprD2 in Carbapenem-Resistance Mechanisms of Pseudomonas aeruginosaSemantic proximity Read ↗

OprD mutations and inactivation, expression of efflux pumps and AmpC, and metallo-β-lactamases in carbapenem-resistant Pseudomonas aeruginosa isolates from South Korea.Semantic proximity Read ↗

Outer membrane permeability of Pseudomonas aeruginosa through β-lactams: new evidence on the role of OprD and OpdP porins in antibiotic resistanceSemantic proximity Read ↗

High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa.Semantic proximity Read ↗

Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein.Semantic proximity Read ↗

Pseudomonas aeruginosa AmpR: an acute-chronic switch regulatorSemantic proximity Read ↗

High-Level Resistance to Colistin Mediated by Various Mutations in the crrB Gene among Carbapenemase-Producing Klebsiella pneumoniae.Semantic proximity Read ↗

NtrC-dependent regulatory network for nitrogen assimilation in Pseudomonas putida.Semantic proximity Read ↗

Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex.Semantic proximity Read ↗

Classification of OprD sequence and correlation with antimicrobial activity of carbapenem agents in Pseudomonas aeruginosa clinical isolates collected in Japan.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.