Article
Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ.
Antimicrobial agents and chemotherapy - 1 Feb 2001
Chuanchuen R, Beinlich K, Hoang T T, Becher A, Karkhoff-Schweizer R R, Schweizer H P
Abstract excerpt
Triclosan is an antiseptic frequently added to items as diverse as soaps, lotions, toothpaste, and many commonly used household fabrics and plastics. Although wild-type Pseudomonas aeruginosa expresses the triclosan target enoyl-acyl carrier protein reductase, it is triclosan resistant due to expression of the MexAB-OprM efflux system. Exposure of a susceptible Delta(mexAB-oprM) strain to triclosan selected...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.