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Article

Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins.

Antimicrobial agents and chemotherapy - 1 Mar 2003

Jo James T H, Brinkman Fiona S L, Hancock Robert E W

Abstract excerpt

The expression of tripartite multidrug efflux pumps such as MexA-MexB-OprM in Pseudomonas aeruginosa contributes to intrinsic resistance to a wide variety of antimicrobials, including beta-lactams, chloramphenicol, macrolides, quinolones, and tetracycline. The MexX-MexY linker-pump combination has been shown to be involved in intrinsic resistance to aminoglycosides, but the identity of the cognate outer membrane...

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Identifiers

PMID: 12604548
DOI: 10.1128/AAC.47.3.1101-1111.2003
PMCID: PMC149301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins.PMID 12604548Read ↗

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A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa.Semantic proximity Read ↗

Identification of Pseudomonas aeruginosa genes associated with antibiotic susceptibility.Semantic proximity Read ↗

Multiple Mutations Lead to MexXY-OprM-Dependent Aminoglycoside Resistance in Clinical Strains of Pseudomonas aeruginosaSemantic proximity Read ↗

Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.Semantic proximity Read ↗

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Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.Semantic proximity Read ↗

Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Regulation, structure, and activity of the Pseudomonas aeruginosa MexXY efflux systemSemantic proximity Read ↗

The role of mex-gene products in antibiotic extrusion in Pseudomonas aeruginosa.Semantic proximity Read ↗

Pseudomonas aeruginosa high-level resistance to polymyxins and other antimicrobial peptides requires cprA, a gene that is disrupted in the PAO1 strain.Semantic proximity Read ↗

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