Article
Sequence determinants of DNA binding by the hematopoietic helix-loop-helix transcription factor TAL1: importance of sequences flanking the E-box core.
Gene expression - 1 Jan 1998
Gould K A, Bresnick E H
Abstract excerpt
TAL1 is a helix-loop-helix transcription factor that is essential for hematopoiesis. In vitro DNA binding site selection experiments have previously identified the preferred binding site for TAL1 heterodimers as AACAGATGGT. TAL1 homodimers do not bind DNA with significant affinity. A subset of ot...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cell Nucleus
- Chromatin
- Cloning, Molecular
- Consensus Sequence
- DNA-Binding Proteins
- Dimerization
- Electrophoresis, Polyacrylamide Gel
- Hematopoiesis
- Humans
- Immune Sera
- Immunosorbents
- Mice
- Mutation
- Oligonucleotides
- Proto-Oncogene Proteins
- Recombinant Proteins