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Article

Corepression of the P1 addiction operon by Phd and Doc.

Journal of bacteriology - 1 Dec 1998

Magnuson R, Yarmolinsky M B

Abstract excerpt

The P1 plasmid addiction operon encodes Doc, a toxin that kills plasmid-free segregants, and Phd, an unstable antidote that neutralizes the toxin. Additionally, these products repress transcription of the operon. The antidote binds to two adjacent sites in the promoter. Here we present evidence concerning the regulatory role of the toxin, which we studied with the aid of a mutation, docH66Y. The DocH66Y protein...

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Identifiers

PMID: 9829946
DOI: 10.1128/JB.180.23.6342-6351.1998
PMCID: PMC107722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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