Article
Epithelial hyperplasia of imaginal discs induced by mutations in Drosophila tumor suppressor genes: growth and pattern formation in genetic mosaics.
Developmental biology - 1 Jun 1995
Agrawal N, Joshi S, Kango M, Saha D, Mishra A, Sinha P
Abstract excerpt
Lethal mutations in the giant discs (lgd) and fat (ft) tumor suppressor genes of Drosophila cause epithelial hyperplasia in all imaginal discs. By contrast, mutations in the vestigial (vg) gene adversely affect cell viability in the wing imaginal discs and consequently cause loss of pattern in the adult wings. However, combining homozygous lgd or ft mutations with homozygous vg1 increases the size of the wing...
Topics
- Animals
- Cell Death
- Cell Division
- Cloning, Molecular
- Drosophila
- Epithelium
- Genes, Insect
- Genes, Tumor Suppressor
- Hyperplasia
- Mesylates
- Mosaicism