Article
The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: rescue of fly lethality by coexpression of apoptosis inducers.
Cell death and differentiation - 1 Oct 2006
Brun S, Rincheval-Arnold A, Colin J, Risler Y, Mignotte B, Guénal I
Abstract excerpt
We carried out gain-of-function mutagenesis screening and identified a mutant in which GAL4 induction led to both hyperplasia and apoptosis. The gene involved was identified as stonewall (stwl), a myb-related gene involved in germ cell proliferation and differentiation during oogenesis. As observed with dmyb, the ectopic expression of stwl(UY823) inhibited endoreplication in salivary glands. We also found that...
Topics
- Alleles
- Animals
- Apoptosis
- Base Sequence
- Cell Cycle
- Cell Proliferation
- DNA, Complementary
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Female