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Article

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent.

The pharmacogenomics journal - 1 Apr 2014

Michaud V, Kreutz Y, Skaar T, Ogburn E, Thong N, Flockhart D A, Desta Z

Abstract excerpt

Efavirenz increases CYP2C19- and CYP3A-mediated omeprazole metabolism. We hypothesized that CYP2C19 and CYP2B6 genetic polymorphisms influence the extent of induction of omeprazole metabolism by efavirenz. Healthy subjects (n=57) were administered a single 20 mg oral dose of omeprazole on two occasions: with a single 600 mg efavirenz dose; and after a 17-day treatment with efavirenz (600 mg per day). DNA was...

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Identifiers

PMID: 23629159
DOI: 10.1038/tpj.2013.17
PMCID: PMC3740059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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